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The Research Goal: Is the study looking for a minimal effective dose or a maximum tolerated dose

Response: We acknowledge commenter's concern about outdated data and collection periods that do not always align across measures

If you find the 45 unit mark uncomfortably small to read, the honest options are (a) use a finer-gradation syringe, or (b) follow a protocol built around the 50 mg vial, whose larger draw is more forgiving not to freehand a bigger volume from the 10 mg vial, which would silently overdose relative to the documented figure

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